Breakthrough role was as a drug addicted fashion designer in Darren Aronofsky's "Requiem for a Dream"
Played a spoiled rich girl, opposite Frank Whaley in John Hughes' "Career Opportunities"
Played Nick Nolte's mistress whose death is at the center of a mystery in "Mulholland Falls"
Played Patrick Wilson's wife in Todd Field's "Little Children"
Portrayed one of three alluring sisters in "Inventing the Abbotts"; first collaboration with Billy Crudup
Began modeling and doing commercials at age ten; continued working as a model until her teens
Lent her voice to the feature-length adaptation of Shane Acker's short film, "9"
Made feature acting debut in "Once Upon a Time in America"; played Elizabeth McGovern's character as a child
Portrayed a collegiate lesbian in John Singleton's "Higher Learning"
Raised in Brooklyn Heights, New York
Starred in the thriller "Dark Water," which was based on a Japanese film
Acted in the Terry George directed "Reservation Road" with Joaquin Phoenix
Co-starred as Rufus Sewell's estranged spouse in "Dark City"
Co-starred in the remake of the 1951 science fiction movie "The Day the Earth Stood Still"
Played a journalist in Edward Zwick's "Blood Diamond" opposite Leonardo DiCaprio
Played Alicia Nash, the long-suffering wife of schizophrenic mathematician, John Forbes Nash, Jr. (played by Russell Crowe) in Ron Howard's film "A Beautiful Mind"
Played Jackson Pollock's mistress in the biopic "Pollock" starring and directed by Ed Harris
Re-teamed with Crudup for the romantic drama "Waking the Dead"
Cast opposite Eric Bana in Ang Lee's "The Hulk"
Joined an ensemble cast for the feature adaptation of the bestselling book, "He's Just Not That Into You"
Played a recovering addict trying to save her home in Vadim Perelman's "House of Sand and Fog"
Starred in the coming-of-age movie "Seven Minutes in Heaven"
Played Naameh in Aranofsky's "Noah"
Starred in Ewan McGregor's directorial debut, "American Pastoral"
Provided voice of Karen in "Spider-Man: Homecoming," the equivalent to husband Bettany's previous character Jarvis
Landed roles in "Snowpiercer" TV series, "Alita: Battle Angel," and "Top Gun: Maverick"
Played a teenager who wishes her baby brother into the world of goblins ruled by king Jareth (David Bowie) in "Labyrinth"
Cast as the female lead opposite Bill Campbell in "The Rocketeer"
Starred in husband Paul Bettany's directorial debut, "Shelter," opposite Anthony Mackie