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Although Jack Haley and Boris Karloff were originally cast as the male leads in this film, both actors bowed out of the production shortly before filming began, according to Hollywood Reporter. Haley declined the part because he felt the role was inappropriate for him and willingly abrogated his RKO contract, under which he owed the studio another picture. Karloff left the production a day after Haley. Margaret Lindsay then replaced June Clayworth in the role of "Connie." Earl Derr Biggers' novel and George M. Cohan's play were also the source for four previous films, all titled Seven Keys to Baldpate: a 1917 Artcraft picture, directed by Hugh Ford and starring George M. Cohan (see AFI Catalog of Feature Films, 1911-20; F1.3939); a 1925 Paramount release, directed by Fred Newmeyer and starring Douglas MacLean; a 1929 RKO release, directed by Reginald Barker and starring Richard Dix (see AFI Catalog of Feature Films, 1921-30; F2.4920 and F2.4921); and a 1935 RKO production, directed by Willaim Hamilton and Edward Killy and starring Gene Raymond (see AFI Catalog of Feature Films, 1931-40; F3.3974). In the first three versions, the action in the inn is revealed at the end to be either a dream or an enactment of "Magee's" novel.